Nicotinamide mononucleotide (NMN) is a very powerful molecule naturally produced in the body and present in small amounts in certain foods.
It fuels energy metabolism by boosting NAD (nicotinamide adenine dinucleotide), a key compound for DNA repair, cellular health, and longevity.
Fascinating emerging research suggests NMN supplements may help combat age-related decline, improve metabolism, and promote overall vitality.
NMN is available as a dietary supplement, and can usually be found in capsule or powder form.
While it is found in some foods, dietary sources provide only small (trace) amounts. Supplementation may be a more effective way to boost NAD levels, though factors affecting individual absorption can vary.
Small quantities of NMN occur naturally in foods such as edamame, cabbage, and raw beef. However, these sources may not provide enough to make any significant impact on NAD production. It’s why researchers have focused primarily on NMN supplementation as a potential way to support cellular health.
NMN helps fuel NAD production, which is needed for mitochondrial function and cell repair. As NAD levels decline with age, it is thought that supplementing with NMN may help counteract some effects of ageing.
NMN is linked to cognitive function and vascular health (of blood vessels). By supporting NAD levels, it may help maintain memory, protect against oxidative stress, and promote healthy blood flow.
Some research suggests NMN may help improve insulin sensitivity, potentially benefiting those with metabolic concerns such as prediabetes.
Studies in athletes indicate that NMN may enhance endurance and aerobic capacity, due to its role in cellular energy production.
Studies indicate NMN is well tolerated, with doses up to 1,200 mg per day showing minimal side effects.
Those with known medical conditions should seek professional advice before use.
Age-related cognitive decline
Cardiovascular health
Metabolic disorders
Muscle function and endurance
Insulin sensitivity
Memory , Brain Health , Brain Fog , Concentration and Cognition , Cardiovascular Health / Cardiovascular Disease (CVD) , Blood Sugar Balance , Metabolic syndrome , Diabetes , Post Exercise Recovery
Shade C. The science behind NMN—a stable, reliable NAD+ activator and anti-aging molecule. Integr Med (Encinitas).2020 Feb;19(1):12-14. PMID: 32549859; PMCID: PMC7238909.
Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi:10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.
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Huang H. A multicentre, randomised, double-blind, parallel design, placebo-controlled study to evaluate the efficacy and safety of Uthever (NMN supplement), an orally administered supplementation in middle-aged and older adults. Front Aging. 2022 May 5;3:851698. doi:10.3389/fragi.2022.851698. PMID: 35821806; PMCID: PMC9261366.
Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021 Jul 8;18(1):54. doi:10.1186/s12970-021-00442-4. PMID: 34238308; PMCID: PMC8265078.
Wen J, Syed B, Kim S, Shehabat M, Ansari U, Razick DI, Akhtar M, Pai D. Improved physical performance parameters in patients taking nicotinamide mononucleotide (NMN): a systematic review of randomized control trials. Cureus. 2024 Aug 1;16(8):e65961. doi:10.7759/cureus.65961. PMID: 39221308; PMCID: PMC11365583.
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