We take a dive into the numerous potential benefits of Black Seed Oil (Nigella sativa), a powerful natural remedy that has been valued for its potential health advantages.
Native to Southern Europe, North Africa and Southwest Asia, Black seed oil is gaining reputation for its healing properties with a rich cultural background and history of use in traditional medicinal practices such as Ayurveda. In many cultures Black Seed is revered as one of the greatest forms of healing medicine available. It was mentioned that black seed is the remedy for all diseases except death in one of the Prophetic Hadith. Traditional
applications of Black Seed Oil include reducing blood pressure, a tonic for the liver, a urinary-flow stimulant, pain reducing action, antibacterial action, appetite stimulant and use in skin disorders. Black seed has also been used for anti-diabetic action and for intestinal parasites. Most of the therapeutic benefits may be attributed to the thymoquinone content (30%-48%), which is a major active component of Black seed oil. Thymoquinone is known to be particularly beneficial for respiratory health. Black seed also contains water soluble triterpenes and saponin, a potential anticancer agent. The seeds reported to contain a fatty oil rich in unsaturated fatty acids, mainly linoleic acid (50-60%), oleic acid (20%) and dihomolinoleic acid (10%). These fatty acids are used local hormones the body produces to regulate inflammation and in located and cell membranes[i].
Black seed oil benefits are seen to control symptoms in asthma [ii]. Black seed also contains nigellone which is thought to be beneficial in the treatment of many lung conditions [iii].
A clear inhibition of the growth of Staphylococcus aureus, H. pylori and various strains of Candida Albicans [iv] [v]
[vi].
It was suggested that dietary supplementation of black seeds extracts inhibits oxidative stress [vii]. Oxidative stress can lead to the production of free radicals. When there are more free radicals present than can be kept in balance by antioxidants, the free radicals may begin damaging fatty tissue, DNA, and proteins in your body. This damage commonly leads to diseases such as cardiovascular disease, diabetes and cancer.
N. sativa and TQ may prove clinically useful in the treatment of diabetics and in the protection of pancreatic cells against oxidative stress [viii]. An improvement of carbohydrate metabolism was seen in diabetic rats [ix].
The effects of different N. sativa seed extracts as an additional cancer therapy to primary care, was seen in human breast cancer cells [x]. Black seed oil also caused an anti-inflammatory effect which inhibited the growth of many types of tumors in studies [xi].
Studies showed black seed oil to result in improvements in allergic rhinitis symptoms, osteoporosis and general encouragement of anti-inflammatory pathways, via the special types of fatty acids black seed oil contains [xii] [xiii]
[xiv].
Studies show black seed oil enhances the action of immune cells such as natural killer cells and other white blood cells. It also stabilises immune pathways such as the T-helper cell ratio [xv].
Studies show Black seed to protect the function of organs such as the heart, stomach, liver and kidneys [xvi].
Long term use of Nigella sativa increased the happiness-promoting hormone serotonin levels in brains of rats and proved to enhance learning and memory [xvii].
Long-term use of black seed is as yet unconfirmed, however studies suggest there are no risks of toxicity associated with long term, moderate use. It may be worth checking any interactions in concomitant medications with your GP as Black Seed may potentially either raise or lower the amount of medicines taken up within the digestive tract and via minor alterations of metabolic processes in the liver (1).
Skin Support , Acne , Stretch Marks , Pigmentation , Breast tenderness , Dermatitis , Inflammation , Allergies (Respiratory) , Brain Fog , Brain Health , Liver Support , Immunity , Pain , Premenstrual Tension/ Syndrome , Blood Sugar Balance , Viral Infection , Fungal Infection
[i] Ahmad, A. Husain, A. Mujeeb, M. et al. (2013). ‘A review on therapeutic potential of Nigella sativa: A miracle herb’. Asian Pacific journal of tropical biomedicine. 3(5) pp.337–352.
[ii] Boskabady, M.H. Javan, H. Sajady, M. et al. (2007) ‘The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients’. Fundamental Clinical Pharmacology. 21(5):559–566.
[iii] Wienkötter N, Höpner D, Schütte U, et al . (2008) ‘The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance’. Planta Med.74(2):105-8. doi: 10.1055/s-2008-1034280. Epub 2008 Jan 24. PMID: 18219598.
[iv] Bakathir, H.A. & Abbas, N.A. (2011) ‘Detection of the antibacterial effect of Nigella sativa ground seeds with water’. African Journal of Traditional, Complementary and Alternative Medicines. 8(2):159–164
[v] Bita, A. Rosu, A.F. Calina, D. et al (2012) ‘An alternative treatment for Candida infections with Nigella sativa extracts’. European Journal of Hospital Pharmacy. 19: (162).
[vi] Salem, E.M. Yar, T. Bamosa, A.O. et al. (2010) ‘Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia’. Saudi Journal of Gastroenterology. 16(3): pp.207–214
[vii] Al-Othman, A. M. Ahmad, F. Al-Orf, S. et al. (2006) ‘Al-Murshed KS, Ariff Z. Effect of dietry supplementation of Ellataria cardamun and Nigella sativa on the toxicity of rancid corn oil in rats’. International Journal of Pharmocology.2(1):60–65.
[viii] Salama RH. Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model. International Journal of Health Sciences (Qassim) 2011;5(2):126–134.
[ix] Abdelmeguid NE, Fakhoury R, Kamal SM, et al. (2010) ‘Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats’. Journal of Diabetes. 2(4):256–266.
[x] Mahmoud SS & Torchilin VP (2012). ‘Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin’. Cell Biochemistry Biophysics. 25(7): pp.1392–1398.
[xi] Peng L, Liu A, Shen Y. et al. (2013) ‘Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway’. Oncology Reports. 29(2):571–578
[xii] Shuid AN, Mohamed N, Mohamed IN, et al. (2012) ‘Nigella sativa: A potential antiosteoporotic agent’. Evidience Based Complementary Alternative Medicine. 696230
[xiii] El Mezayen R, El Gazzar M, Nicolls MR, et al. (2006) ‘Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation’ Immunology Letters. 15;106(1):72-81.
[xiv] Nikakhlagh S, Rahim F, Aryani FH, et al. (2011) ‘Herbal treatment of allergic rhinitis: the use of Nigella sativa’. American Journal of Otolaryngology 32(5):402–407
[xv] Majdalawieh AF, Hmaidan R, Carr RI. (2010) ‘Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity’. Journal of Ethnopharmacology
. 131(2):268–275.
[xvi] Ahmad, A. Husain, A. Mujeeb, M. et al. (2013). ‘A review on therapeutic potential of Nigella sativa: A miracle herb’. Asian Pacific journal of tropical biomedicine. 3(5) pp.337–352.
[xvii] Perveen T, Abdullah A, Haider S, et al. (2008) ‘Long-term administration of Nigella sativa effects nociceotion and improves learning and memory in rat’s. Pakistan Journal of Biochemistry & Molecular Biology
.41(3):141–143.
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