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SOD

What is SOD?


Superoxide dismutase (SOD) is an enzyme found in nearly all living cells. It acts as a defence system, neutralising harmful oxygen radicals that can damage cells. Without it, oxidative stress would accelerate ageing and contribute to various diseases.


How can I take SOD?


SOD is used in creams to support skin health and oral supplements for antioxidant defence. While topical forms are widely accepted, the effectiveness of tablets depends on absorption and formulation quality.


Where is SOD found?


SOD exists naturally in plants, animals, and microorganisms. In humans, it’s found inside cells (cytosol and mitochondria) and in extracellular fluids, where it helps neutralise oxidative stress. Some supplements are derived from bovine sources or from certain fruits like melons.


What is SOD used for?


Protects skin health: Because Superoxide dismutase (SOD) is gaining attention as a powerful antioxidant enzyme that fights inflammation and oxidative stress — by reducing damage, it potentially strengthens the skin barrier. Helps reduce wrinkles, fine lines, and age spots while supporting wound healing, softening scar tissue, shielding against UV damage, and minimising other visible signs of ageing.


Supports longevity and disease prevention: Current research links it to protection against neurodegenerative diseases and cardiovascular issues. It is also thought to help manage chronic inflammation.


The potential benefits of SOD include:


  • Joint and inflammatory conditions – Some studies suggest SOD may help ease inflammation in conditions like osteoarthritis and rheumatoid arthritis, potentially reducing joint pain and stiffness.

  • Skin protection and anti-ageing – SOD is used in skincare for its ability to combat oxidative stress, which can contribute to UV damage and premature ageing. A study highlights superoxide dismutase (SOD) as a key antioxidant enzyme that neutralises reactive oxygen species (ROS) in skin. Ageing and environmental pollutants can disrupt SOD activity, contributing to oxidative stress, inflammation, and reduced skin barrier function, accelerating extrinsic skin ageing.

  • Brain and cardiovascular health – SOD deficiency has been linked to Alzheimer’s disease, stroke, and vascular injury (injury to blood vessels). A study also details that reduced SOD activity correlates with increased oxidative stress, mitochondrial dysfunction (in the energy factories in our cells), and inflammation. These are all key contributors to neurodegeneration and vascular impairment​. Therefore, SOD helps prevent oxidative damage in the brain and heart. Low levels are linked to memory loss, stroke risk, and blood vessel damage.

  • Cellular protection – SOD converts harmful superoxide radicals into less harmful substances such as small amounts of hydrogen peroxide and oxygen, preventing DNA, protein, and membrane damage.


Is it safe?


SOD from food sources and skincare products is generally considered safe.


Those with specific health conditions should consult a professional prior to supplementation.


Key takeaways for SOD:


  • Oxidative stress reduction

  • Skin health and anti-ageing

  • Inflammation control

  • Neuroprotection

  • Cardiovascular protection

Recommended For

Neurodegenerative Disease , Arthritis (Osteo) , Cardiovascular Health / Cardiovascular Disease (CVD) , Ageing , Age spots

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