Vitamin A is a fat-soluble vitamin, which means we store it in the body, mostly in the liver. Vitamin A supports eye health[1], skin health[2], immunity[3] and also helps to heal the epithelial tissue.
Firstly, it is worth understanding there are two forms of Vitamin A. What is the difference between vitamin an and betacarotene? Vitamin A is a nutrient that is essential for various bodily functions, while beta-carotene is a precursor to vitamin A that can be converted into vitamin A by the body when needed.
Beta carotene: Sweet potato, dark green leafy veg and carrots[6], apricots, broccoli, dandelion greens, red and orange peppers and butternut squash.
Vitamin A: liver, eggs, milk and fish.
This makes it useful for reducing symptoms of intestinal permeability (leaky gut) other mucous membrane related issues[4]. It can help prevent infections in the immune system such as colds and flues and also other body parts such as the kidneys, bladder and lungs.
Additionally, vitamin A plays an important role in the formation and development of bones and teeth and also acts as an antioxidant. Its antioxidant abilities make it an important player in cancer prevention and also helps with new cell growth.
Vitamin A is a group of unsaturated organic compounds, which include retinol, retinal, and retinoic acid[5]. A set of compounds called carotenoids (of which there are over 500 different ones) act as precursors of vitamin A (also called provitamin A) and also as antioxidants. The most well-known one is beta-carotene which is converted into vitamin A in the liver. Beta-carotene scavengers and/or neutralises free radicals making it a potent antioxidant. Other carotenoid groups are the xanthophylls and phytosterols. Lutein is a phytosterol and is preventative against the risk of cataracts, age-related macular degeneration and prostate cancer.
Deficiency of vitamin A can lead to dry skin and hair, dry cornea and conjunctiva and night blindness. Other issues sometimes related to vitamin A deficiency are abscesses in the ear, reproductive issues, fatigue and insomnia, sinusitis, pneumonia and acne.
As vitamin A is stored in the liver, you should not take high doses long term as it can become toxic. Symptoms of toxic levels are abdominal pain, amenorrhea, enlarged liver or spleen, hair loss, itching, joint pain, nausea/vomiting and cracks in the corner of your mouth. There is caution for pregnant women taking vitamin A in high amounts leading to birth defects such as cleft palate.
Beta-carotene is considered a safer form to supplement in high doses than vitamin A as it is not harmful in large amounts and does not have the same effect as vitamin A has on the liver.
Daily recommended allowances for adults: 600-700ug/day
Carotenoids are best taken in combination rather than individually.
Dry Eyes , Eye Health , Acne , Acne Marks/ Scars , Osteoporosis , Fertility - Female , Fertility - Male , Dry Skin
[1] Eggersdorfer M, Wyss A. Carotenoids in human nutrition and health. Arch Biochem Biophys. 2018 Aug 15;652:18-26. doi: 10.1016/j.abb.2018.06.001. Epub 2018 Jun 6. PMID: 29885291.
[2] Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, Kalkan G. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014 Jun;33(2):99-102. doi: 10.3109/15569527.2013.808656. Epub 2013 Jul 5. PMID: 23826827.
[3] Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr. 2001;21:167-92. doi: 10.1146/annurev.nutr.21.1.167. PMID: 11375434.
[4] He C , Deng J , Hu X , Zhou S , Wu J , Xiao D , Darko KO , Huang Y , Tao T , Peng M , Wang Z , Yang X . Vitamin A inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins. Food Funct. 2019 Feb 20;10(2):1235-1242. doi: 10.1039/c8fo01123k. PMID: 30747184.
[5] Tanumihardjo SA, Russell RM, Stephensen CB, et al. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr. 2016;146(9):1816S-48S. doi:10.3945/jn.115.229708
[6] Saeed A, Dullaart RPF, Schreuder TCMA, Blokzijl H, Faber KN. Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients. 2017;10(1):29. Published 2017 Dec 29. doi:10.3390/nu10010029
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