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Grapefruit Seed Extract

Citrus × paradisi

What is Grapefruit Seed Extract?

Grapefruit seed extract or citrus seed extract is a supplement made from the seeds and pulp of grapefruit. It’s rich in essential oils and antioxidants and has a variety of potential health benefits.

What are the potential health benefits of grapefruit seed extract?


Uses in naturopathic medicine include applications for acne, athletes foot, cold sores, vaginal infections and infections such as the common cold and sore throat.

Anti-candida actions

It has also seen to be effective against fungal candida infections Candida infection most commonly occurs in the mouth, ears, nose, toenails, fingernails, gastrointestinal tract and vagina. One particular study found 33 percent strength grapefruit extract has a potent antifungal effect against Candida albicans strains taken from patients with candida symptoms[i]. [ii].

Antimicrobial actions

Research has suggested the extract to be effective against many bacterial strains such as Staphylococcus aureus and Escherichia coli [iii]. It breaks down of outer membranes of bacteria and fungi, causing them to burst open. As such, Grapefruit Seed Extract is seen in the light of some research as a natural-derived antibacterial substance against antibiotic resistant bacteria [iv].

Urinary Tract Infection (UTIs)

Applications of grapefruit seed extract for chronic or drug-resistant urinary tract infections (UTIs) have been reported in studies. Data suggests an antibacterial property of dried or fresh grapefruit seeds, when taken at a dosage of 5 to 6 seeds every 8 hours, is comparable to that of proven antibacterial drugs [v].

Antioxidant benefits

Grapefruit seed extract also contains a polyphenol called naringenin, which acts as an antioxidant. Antioxidants help to prevent cellular damage via free radicals, which can lead to chronic diseases such as cardiovascular disease. Naringenin, the flavonoid is said to have cell protecting actions on the gastric mucosa which lines our intestinal tract [vii]. Analysis shows the active phytochemicals of the seed extract and pulp, are flavonoids, ascorbic acid (Vitamin C), vitamin E, plant sterols and minerals [vi].

Stomach ulcers

Animal studies found grapefruit seed extract to have properties which aid the healing of stomach ulcers and may prevent them from reoccurring. This effect was said to be due to an increase in gastric microcirculation [viii] [ix].

Helicobacter pylori infection is the most common cause of gastritis and stomach ulcers. Grapefruit seed extract has been highlighted as a potential alternative anti-H. pylori therapy, due to its inhibition of H. pylori growth in both test tube and animal studies [x].

Safety and precautions

Do not exceed intended dose, Use as described on the product packaging or as prescribed by your health practitioner.

Pregnancy and breastfeeding

While grapefruit consumed in its food form is generally recognised as safe during pregnancy and breastfeeding, there is not enough evidence to suggest that concentrated formulas of grapefruit seed extract may be used.


Please note: Phytochemicals in grapefruit seeds, particularly furanocoumarins and flavonoids, may cause adverse effects on health resulting from grapefruit–drug interactions that influence the intended therapeutic effects of many prescription drugs [xi]. Taking grapefruit in any supplemental form, or in the diet and juices is not advised if taking medication as it can interact with many forms of medication.

Recommended For

Anti-Fungal , Fungal Infection , Viral Infection , Urinary Tract Infection (UTI) , Skin Support , Helicobacter Pylori

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