Oregano gained popularity in the ancient Greek and Roman civilisations, where it was used for its medicinal properties. The herb has also been used for centuries as a culinary spice, famous in Italian cuisine.
Oregano essential oil is made by air-drying the leaves and shoots of the plant. Once they’re dried, the oil is extracted and concentrated by steam distillation. Oregano essential oil can be mixed with a carrier oil and applied on the skin for alleviating infections, such as fungal nail and many others. However, it is advised that it should not be consumed orally.
Oregano oil extract, can be produced via several extraction methods using compounds like carbon dioxide or alcohol. In this form it is widely available as a supplement and can often be found in pill or capsule form.
Carvacrol: The most abundant phenol in oregano, it has been shown to stop the growth of several different types of bacteria [i].
Thymol: This natural anti-fungal can also support the immune system and protect against toxins [ii].
Rosmarinic acid: This powerful antioxidant helps protect against damage caused by free radicals [iii].
Oregano oil has been shown to kill microbes such as bacteria, fungi and viruses. The Staphylococcus aureus bacterium is one of the most common causes of infection, resulting in ailments like food poisoning and skin infections. In mice, oregano oil had antimicrobial action against Staphylococcus aureus [iv]. Research has also shown that oregano essential oil may be effective against some potentially antibiotic-resistant bacteria [v] [vi].
Studies also show oregano oil to be effective against many strains of candida known to cause yeast infections in women [vii] [viii].
Oregano also displayed antimicrobial action against gut parasitic infections, and successfully reduced associated symptoms in patients [ix].
Antioxidants help protect the body from damage caused by free radicals. Free radical damage, if left unmanaged by adequate antioxidant action, plays a role in ageing and the development of some diseases, such as heart disease. Gram per gram, oregano also has 42 times the antioxidant level of apples and 4 times that of blueberries. This is thought to be mostly due to its rosmarinic acid content [x].
Evidence from clinical trials suggests oregano to have benefits in terms of cholesterol. In one study, 48 people with mildly high cholesterol were given diet and lifestyle advice to help lower their cholesterol. Thirty-two participants were also given 0.85 ounces (25 mL) of oregano oil extract after each meal. After 3 months, those given the oregano oil had lower LDL (bad) cholesterol and higher HDL (good) cholesterol, compared with those who were just given diet and lifestyle advice [xi].
Limited research exists in terms of oregano and its ability to reduce pain. In animal studies it is suggested the carvacrol content contributes to this effect. Oregano has been compared to standard painkillers [xv] [xvi].
[i] Nostro A, & Papalia T. (2012) ‘Antimicrobial activity of carvacrol: current progress and future prospectives’. Recent Pat Antiinfect Drug Discov.Apr;7(1):28-35.
[ii] de Castro, R.D., de Souza, T.M.P.A., Bezerra, L.M.D. et al. (2015) ‘Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study'. BMC Complement Altern Med 15, 417.
[iii] Bakota, E.L. Winkler-Moser, J.K. Berhow, M.A. et al. (2015) ‘Antioxidant activity and sensory evaluation of a rosmarinic acid-enriched extract of Salvia officinalis’. J Food Sci. 80(4):C711-7.
[iv] Preuss HG, Echard B, Dadgar A, et al. (2005) ‘Effects of Essential Oils and Monolaurin on Staphylococcus aureus: In Vitro and In Vivo Studies’. Toxicol Mech Methods. 15(4):279-85.
[v] Man, A. Santacroce, L. Jacob, R. et al. (2019). ‘Antimicrobial Activity of Six Essential Oils Against a Group of Human Pathogens: A Comparative Study’. Pathogens (Basel, Switzerland), 8(1), 15.
[vi] Sienkiewicz M, Wasiela M, Głowacka A. (2012) ‘Aktywność przeciwbakteryjna olejku oreganowego (Origanum heracleoticum L.) wobec szczepów klinicznych Escherichia coli i Pseudomonas aeruginosa [The antibacterial activity of oregano essential oil (Origanum heracleoticum L.) against clinical strains of Escherichia coli and Pseudomonas aeruginosa]'. Med Dosw Mikrobiol. 64(4):297-307.
[vii] Pozzatti P, Scheid LA, Spader TB, et al. (2008) ‘In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. Can J Microbiol.54(11):950-6.
[viii] Cleff, M. B., Meinerz, A. R., Xavier, M., et al. (2010). ‘In vitro activity of origanum vulgare essential oil against candida species’. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 41(1), 116–123.
[ix] Force M, Sparks WS, Ronzio RA. (2000) ‘Inhibition of enteric parasites by emulsified oil of oregano in vivo’. Phytother Res. 14(3):213-4.
[x] Zheng W, Wang SY. (2001) ‘Antioxidant activity and phenolic compounds in selected herbs’. J Agric Food Chem. 49(11):5165-70.
[xi] Ozdemir B, Ekbul A, Topal NB, et al.(2008) ‘Effects of Origanum onites on endothelial function and serum biochemical markers in hyperlipidaemic patients’. J Int Med Res. 36(6):1326-34.
[xii] Yin, Q. H., Yan, F. X., Zu, X. Y. et al. (2012). ‘Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2’. Cytotechnology, 64(1), 43–51.
[xiii] Arunasree KM. (2010) ‘Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231’. Phytomedicine. 17(8-9):581-8.
[xiv] Jung CY, Kim SY, Lee C. (2018) ‘Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells’. Anticancer Res. 38(1):279-286.
[xv] Aydın, S., Öztürk, Y., Beis, R. et al. (1996) ‘Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia Essential Oils for Analgesic Activity’. Phytother. Res., 10: 342-344.
[xvi] Afarineshe Khaki, M. R., Pahlavan, Y., Sepehri, et al. (2013). ‘Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System’. Iranian journal of pharmaceutical research : IJPR, 12(2), 407–413.
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