Red clover is a wild flowering plant belonging to the same family as peas and beans. It is a dark-pink herbaceous plant originating from Europe, Asia, and North Africa.
Osteoporosis is often associated with menopausal and post-menopausal women due a decline in reproductive hormones, namely oestrogen, which can lead to increased bone turnover and a decrease in the density of bones. Red clover contains isoflavones, which can weakly mimic the actions of oestrogen in the body. Research has shown a connection between isoflavone intake and a decrease in osteoporosis risk [i] [ii]. One particular study on 60 premenopausal women found that taking (150 ml) of red clover extract containing 37 mg of isoflavones daily for 12 weeks resulted in less bone density loss in the lower spine and neck, compared with the placebo group [iii].
It is also thought Red clover’s high isoflavone content may help regulate menopause symptoms, such as hot flashes and night sweats. A study observed a 73% decrease in hot flashes after 3 months of taking a supplement containing red clover, amongst others. Red clover was also seen to improve libido, mood, sleep, and tiredness in menopausal women [iv]. Additionally, some research shows that taking red clover might improve menopausal vaginal dryness [v].
In traditional medicine Red Clover has been used to promote healthy growth and replication of skin, hair and nails. Women in a trial were provided with red clover extract and reported improvements scalp hair and skin status, as compared to placebo [vi].
Male-pattern baldness (androgenic alopecia). Early research shows that applying a combination product containing red clover flower extract might increase hair growth in people with hair loss [vii].
Breast pain (mastalgia). There is some early evidence that red clover might help relieve cyclic breast pain and tenderness, in the menstrual cycle [viii].
You may not be able to use red clover if you have a blood clotting disorder, cancer, endometriosis, or uterine fibroids. Red clover may have estrogen-like effects, which can make certain conditions that are sensitive to estrogen worse. Please check with your doctor before taking supplemental red clover.
[i] Taku, K. Melby, M.K. Nishi, N. et al. (2011) ‘Soy isoflavones for osteoporosis: an evidence-based approach’. Maturitas. 70(4):333-8.
[ii] Sansai, K. Na Takuathung, M. Khatsri, R. et al. (2020) ‘Effects of isoflavone interventions on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials’. Osteoporosis International. 31(10):1853-1864.
[iii] Thorup, A. C. Lambert, M. N. Kahr, H. S. et al. (2015). ‘Intake of Novel Red Clover Supplementation for 12 Weeks Improves Bone Status in Healthy Menopausal Women’. Evidence-based complementary and alternative medicine : eCAM, 2015, 689138.
[iv] Lipovac, M. Chedraui, P. Gruenhut, C. et al. (2011). ‘Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women’. Obstetrics and gynecology international, 2011, 949302.
[v] Hidalgo, L.A. Chedraui, P.A. Morocho, N. et al. ‘The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study’. Gynecological Endocrinology. 21(5):257-264.
[vi] Lipovac, M. Chedraui, P. Gruenhut, C. et al. (2011). ‘Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women’. Obstetrics and gynecology international, 2011, 949302.
[vii] Loing, E. Lachance, R. Ollier, V. et al. (2013) ‘A new strategy to modulate alopecia using a combination of two specific and unique ingredients’. Journal of Cosmetic Science. 64(1):45-58.
[viii] Ingram, D.M. Hickling, C. West, L, et al. (2002) ‘A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia'. The Breast. 2002 ;11:170-4.
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