Copper is a mineral that is required in the body for various functions. It supports[i][ii]:
Red blood cell production
Nerve cell health
Immune system function
Collagen formation
Antioxidant activity
Iron absorption
Energy production
Copper is found in the highest amounts in protein foods like organ meats, shellfish and fish. Nuts and seeds like cashews, almonds, sesame seeds, and sunflower seeds are also good sources of copper. Also, grains like oats, as well as legumes such as lentils and chickpeas, contribute to dietary copper. In addition to this avocados, bananas, and prunes, and dark chocolate are also sources of copper, all be it in smaller amounts[iii].
It is also worth considering that the copper content in foods can vary depending on factors such as soil quality and food manufacturing/ processing methods, but through maintaining a well-balanced and diverse diet that includes these copper-rich foods can help ensure an adequate intake of copper[iv].
While copper deficiency is said to be very rare in occurrence, it is possible via inadequate dietary intake – this can lead to symptoms like anaemia, low body temperature, higher risk of bone fractures, low white blood cell count, irregular heartbeat, skin depigmentation and thyroid issues[v].
Both too much and too little copper can affect how the brain works - impairments have been linked to Alzheimer’s. Some studies associate Alzheimer’s disease with copper deficiency and recommend increasing copper levels[vi].
Copper plays a crucial role in the synthesis and maintenance of collagen and elastin, these are the key components of connective tissues. Connective tissue is a type of tissue in the body that provides support and structure, and insulation for other tissues and organs. Therefore, supplementing with copper could be said to support the health of skin, tendons, ligaments, and blood vessels, promoting their strength and integrity. Studies have found that post-menopausal women with low bone density had very low levels of copper and other minerals in their blood. The study recommended copper supplements as a potential treatment to help improve bone density[vii].
Copper acts as an antioxidant in the body, neutralising harmful free radicals that can damage cells and DNA. By reducing oxidative stress, copper supplementation may contribute to overall cellular health and support the body's defence against chronic diseases[viii].
Copper assists in the absorption and utilisation of iron in the body. It helps convert iron into a form that can be easily absorbed by the intestines[ix].
Copper is involved in important roles for immune response regulation. Therefore, for those who need copper, it may help immune function[x][xi].
Copper is a cofactor for enzymes involved in energy metabolism via the body's primary energy source (ATP). Thus, copper supplementation may help combat fatigue in those who need to supplement it[xii].
Taking high levels of copper should be done under the supervision of a nutritional therapist or other specialist. Talk to us today to get some personalised advice regarding copper[xiii].
Taking too much copper can possibly lead to copper toxicity, which can cause symptoms such as nausea, vomiting, abdominal pain, diarrhoea, and liver damage[xiv].
While copper supplementation is generally safe when taken as directed, some people might get nausea, and metallic taste in the mouth. If you experience any adverse or undesirable reactions, it's important to discontinue use immediately and consult with your prescriber or a specialist[xv].
Copper can interact with zinc and vitamin C. It's important to inform your healthcare provider/ prescriber of any other medications or supplements you are taking, to ensure there are no potential interactions or adverse effects[xvi].
Penicillamine is a medication used for various conditions, including Wilson's disease, a disorder that affects copper metabolism. As such, copper supplements may interfere with the effectiveness of penicillamine[xvii].
Some studies suggest that long-term use of NSAIDs, such as ibuprofen or aspirin, may increase the risk of gastrointestinal bleeding, which can lead to copper deficiency[xviii].
During pregnancy and breastfeeding, it is important to consult with a GP or nutritional therapist before considering copper supplements. This way you can be sure this is the right choice for you, following an assessment of your individual nutritional needs and evaluation of copper status. They can also tailor advice based on your specific circumstances[xix][xx].
That said, it is generally safe to obtain necessary nutrients, including copper, through a well-balanced diet during pregnancy and breastfeeding[xxi].
Image credit Pixels.com
Neurodegenerative Disease , Collagen Production , Immunity , Antioxidants , Neuralgia (Nerve Pain) , Energy
[i] Muriel Bost, Sabine Houdart, Marion Oberli, Esther Kalonji, Jean-François Huneau, Irène Margaritis, Dietary copper and human health: Current evidence and unresolved issues, Journal of Trace Elements in Medicine and Biology, Volume 35, 2016, Pages 107-115.
[ii] National Research Council (US) Committee on Copper in Drinking Water. Copper in Drinking Water. Washington (DC): National Academies Press (US); 2000. 2, Physiological Role of Copper
[iii] Burkhead JL, Collins JF. Nutrition Information Brief-Copper. Adv Nutr. 2022 Mar;13(2):681-683.
[iv] Cristiano Ballabio, Panos Panagos, Emanuele Lugato, Jen-How Huang, Alberto Orgiazzi, Arwyn Jones, Oihane, Fernández-Ugalde, Pasquale Borrelli, Luca Montanarella, Copper distribution in European topsoils: An assessment based on LUCAS soil survey, Science of The Total Environment, Volume 636, 2018, Pages 282-298.
[v] Berkeley L. Bennett, Mary Clyde Pierce, 31 - Bone Health and Development, Editor(s): Carole Jenny, W.B. Saunders, 2011, Pages 260-274
[vi] Bagheri S, Squitti R, Haertlé T, Siotto M, Saboury AA. Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals. Front Aging Neurosci. 2018 Jan 23;9:446.
[vii] Mahdavi-Roshan M, Ebrahimi M, Ebrahimi A. Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women. Clin Cases Miner Bone Metab. 2015 Jan-Apr;12(1):18-21.
[viii] Gaetke LM, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology. 2003 Jul 15;189(1-2):147-63.
[ix] Collins JF, Prohaska JR, Knutson MD. Metabolic crossroads of iron and copper. Nutr Rev. 2010 Mar;68(3):133-47.
[x] Percival SS. Copper and immunity. Am J Clin Nutr. 1998 May;67(5 Suppl):1064S-1068S.
[xi] Cheng F, Peng G, Lu Y, Wang K, Ju Q, Ju Y, Ouyang M. Relationship between copper and immunity: The potential role of copper in tumor immunity. Front Oncol. 2022 Nov 7;12:1019153.
[xii] Medeiros DM, Jennings D. Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidase. J Bioenerg Biomembr. 2002 Oct;34(5):389-95.
[xiii] Royer A, Sharman T. Copper Toxicity. [Updated 2023 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.
[xiv] Magdalena Araya, Manuel Olivares, Fernando Pizarro, Mauricio González, Hernán Speisky, Ricardo Uauy,
Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure 123, The American Journal of Clinical Nutrition, Volume 77, Issue 3, 2003, Pages 646-650,
[xv] Epke EM, McClure ST, Lawless HT. Effects of Nasal Occlusion and Oral Contact on Perception of Metallic Taste from Metal Salts. Food Qual Prefer. 2009 Mar;20(2):133-137.
[xvi] Jiang R, Sui Y, Hong J, Niimi M, Yan Q, Shi Z, Yao J. The Combined Administration of Vitamin C and Copper Induces a Systemic Oxidative Stress and Kidney Injury. Biomolecules. 2023 Jan 10;13(1):143.
[xvii] Martins da Costa C, Baldwin D, Portmann B, Lolin Y, Mowat AP, Mieli-Vergani G. Value of urinary copper excretion after penicillamine challenge in the diagnosis of Wilson's disease. Hepatology. 1992 Apr;15(4):609-15.
[xviii] Hussain A, AlAjmi MF, Rehman MT, Amir S, Husain FM, Alsalme A, Siddiqui MA, AlKhedhairy AA, Khan RA. Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies. Sci Rep. 2019 Mar 27;9(1):5237.
[xix] Kodama H, Anan Y, Izumi Y, Sato Y, Ogra Y. Copper and zinc concentrations in the breast milk of mothers undergoing treatment for Wilson's disease: a prospective study. BMJ Paediatr Open. 2021 Jun 17;5(1):e000948.
[xx] Gluckman, Sir Peter, and others, 'Copper in pregnancy and breastfeeding', Nutrition and Lifestyle for Pregnancy and Breastfeeding (Oxford, 2014; online edn, Oxford Academic, 1 Jan. 2015).
[xxi] Magnus Domellöf, Bo Lönnerdal, Kathryn G Dewey, Roberta J Cohen, Olle Hernell, Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status123, The American Journal of Clinical Nutrition, Volume 79, Issue 1, 2004, Pages 111-115.
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