Methylation is involved in a variety of functions in the body, such as:
Regulating mood and sleep by producing neurotransmitters such as dopamine, serotonin, adrenaline, and melatonin and supporting energy production
Regulating hormones, including those needed for healthy menstrual cycles
Methylation is particularly important for children, pregnant women, and those with chronic diseases such as heart disease or diabetes
Detoxifying environmental toxins and heavy metals
Supporting bile production, which is necessary for digestion and absorption of fats and fat-soluble vitamins
Protecting our nerves cells, which ensures appropriate nervous function and mental cognition
Producing immune cells needed for protection against disease and detoxifying excess histamine, which is associated with allergies such as asthma or hay fever
Hormonal imbalances, such as PMS, endometriosis, PCOS, and irregular or heavy periods
Infertility in both males and females, as well as pregnancy-related complications like pre-eclampsia
Autoimmune conditions like multiple sclerosis, rheumatoid arthritis, and autoimmune thyroid disorders
Allergies, including eczema, hay fever, asthma
Mental health conditions like depression, anxiety and general mood fluctuations
Neurodegenerative diseases like dementia and Alzheimer's disease
Chronic fatigue syndrome (CFS), ME, and fibromyalgia.
Optimising methylation through a healthy diet and lifestyle, as well as targeted supplementation, may help reduce the risk of these health problems and improve overall health and well-being.
Taking a good quality multivitamin containing methylfolate and methylcobalamin can provide a baseline for overall methylation support. Liquid forms of individual nutrients may be useful if you require a specific dose, struggle with digestive issues, or find it difficult to swallow capsules. Try the following:
Pure Encapsulations Homocysteine Factors: Supports cardiovascular health, containing methylated B vitamins. Made with hypoallergenic, vegan ingredients.
Cytoplan Methyl Factors (60 Caps): Methyl Factors has been developed to help support those who need extra methyl donor nutrients to facilitate this process in the body.
Viridian High Twelve B-Complex B12 - Vitamin B12: Each of the Viridian B-complex supplements offers a full array of the B vitamins together with a higher level of a featured B vitamin. This supplement features a higher levels of methylcobalamin and cyanocobalamin (vitamin B12).
Cytoplan Sublingual Vitamin B12 - Methyl and Adenosylcobalamin (60 caps): A high potency active B12 supplement containing a combined dose of 1mg of methylcobalamin and adenosylcobalamin (i.e. 500µg of each).
Genetic Testing: We work with the leading genetic testing facilities to offer the latest in nutrigenomic testing.
Metabolomix Plus: This test provides a unique and comprehensive assessment of nutritional status. A fully detailed analysis is provided of individual vitamins, minerals, phytonutrients and amino acids status, as well as markers for gastrointestinal function and oxidative stress.
Complete Hormone Panel - DUTCH Test: DUTCH (Dried Urine Test for Comprehensive Hormones) Complete can help identify the root causes of hormone imbalances in men and women. It can provide insights into conditions such as the menopause, PCOS, weight gain, fatigue, low libido, premenstrual syndrome, mood swings, sleep issues, mood disorders and prostate issues in men. The analysis includes an interpretation chart looking at methylation factors, amongst many others.
Methylation is interdependent on other processes and systems in the body and can be influenced by both environmental and psychosocial factors. A truly comprehensive approach to supporting methylation involves addressing all of these factors simultaneously. This includes improving and cleaning up our diet, reducing our overall toxic load, improving sleep quality, and managing stress, while supplementing with specific and bioactive nutrients tailored to our individual needs. While this may seem daunting, even small steps towards these goals can pay. Starting with just one area at a time can help you make progress towards optimal methylation and overall health. You will soon see the results of the effort you put in.
[i] McCaddon A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013; 95(5):1066-1076.
[ii] Wang XX et al. Genome-wide DNA methylation and gene expression patterns provide insight into polycystic ovary syndrome development. Oncotarget. 2014;5(16):6603-6610.
[iii] Donnan J et al. A systematic review of the risk factors associated with the onset and natural progression of spina bifida. Neurotoxicology. 2016. [Epub ahead of print].
[iv] Neven KY et al. Repetitive element hypermethylation in multiple sclerosis patients. BMC Genet. 2016;17(1):84
[v] Gandolfo G et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Vak158Met with mood disorders. J Affect Disord. 2015; 177:108-113.
[vi] Shaik Mohammad N et al. Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders. Psychiatr Genet. 2016;26(6):281-286.
[vii] Liu A et al. Analysis of the MTHFR C677T variant with migraine phenotypes. . BMC Research Notes 2010;3:213.
[viii] Wernimont SM et al. Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans. J Nutr.2011;141(2):255-60.
[ix] Frosst P et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-13.
[x] Rima D, et al. Oxidative Stress Induced Damage to Paternal Genome and Impact of Meditation and Yoga - Can it Reduce Incidence of Childhood Cancer? Asian Pac J Cancer Prev. 2016;9;17(9):4517-4525.
[xi] Harkess KN et al. Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Translational Psychiatry. 2016;6(11):e965.
[xii] Ren H. et al. Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks. Evidence-Based Complementary and Alternative Medicine, 2012:Article ID 841810: 9 pages.
[xiii] Food Standards Agency. Survey of total and inorganic arsenic in rice drinks. Last updated: May 2009. Available at: https://www.food.gov.uk/scienc...
[xiv] Monrad M et al. Low-level arsenic in drinking water and risk of incident myocardial infarction: a cohort study. Environ Res. 2017; 154: 318-324
[xv] Rossi M, Amaretti A, Raimondi S. Folate Production by Probiotic Bacteria. Nutrients. 2011;3(1):118-134.
[xvi] Gibson GR, Beatty ER, Wang X & Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterol. 1995 108:975-982.
[xvii] Bouhnik Y et al. Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Nutr Cancer. 1996;26(1):21-9.
[xviii] Thakur VS et al. Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention. The AAPS Journal. 2014;16(1):151-163.
Please note that the information contained within this website does not and should not replace medical advice, and is not intended to treat or diagnose. We always recommend you consult with your doctor. Our Nutritional Therapy team is highly trained and we offer one to one Nutritional Therapy Consultations, which are designed to be complementary to any medical treatment from a functional medicine approach, as well as offering a preventative & optimal health focus.