The adrenal stress profile measures adrenal cortex function and the circadian fluctuation in the hormones cortisol and DHEA. The test is taken with a number of saliva samples taken at specific times of the day and the results graphed in an easy to understand chart to assess circadian cortisol response as a marker of the stress response. This profile can be used to identify an inappropriate adrenal function, and aid in assessing how it is influencing a crucial marker of the immune system.

This test also includes the optional Cortisol Awakening Response (CAR) markers that we usually undertake at the same time as the foundation Adrenal test as this provides a more complete picture of the stress response. CAR is a transient, immediate rise in cortisol upon awakening and is distinct from the diurnal rhythm. CAR reflects a person's ability to cope with anticipated challenges and their perception of control around chronic stress.

Daily hassles, chronic pain, blood sugar dysregulation, work stressors, and poor relationship quality can alter the HPA axis. Imbalances in adrenal hormones can have a wide range of negative consequences that can adversely impact a patient's overall quality of life. The symptoms of HPA axis dysfunction can be vague, and are highly variable, but may include: fatigue, insomnia, weight gain, depression, GI complaints, and chronic pain. HPA axis dysfunction is associated with many conditions including:

• hypertension
• cardiovascular disease
• gastrointestinal and immune dysregulation
• diabetes and metabolic syndrome
• depression
• chronic fatigue
• persistent pain
• neurodegenerative disease and cognitive decline

Adrenal Stress Profile testing can reveal these HPA axis imbalances and provide direction for clinical intervention with targeted therapeutic treatments, such as nutrient support and/or adaptogens, stress management, behavioral modification, and lifestyle interventions.

As with the majority of our Functional Tests and in accordance with clinical guidelines, a full Initial Nutrition Consultation is required before running this test with a member of our Nutritional Therapy team. The practitioner can then assess your needs and provide guidance on a Nutrition Plan which may include recommendations for Functional Nutrition Tests if these are deemed useful to influence the guidance. A full test interpretation is then provided during a Follow Up Nutrition Consultation with recommendations put in place taking into account your test results alongside your clinical presentation and health goals.